Description

5-Methyl-2-Thiouridine is a modified nucleoside analog of significant interest in biochemical and pharmaceutical research. This compound is valued for its role in studying RNA structure, function, and the mechanisms of nucleoside metabolism. It serves as a critical building block and research tool for scientists in the fields of molecular biology, medicinal chemistry, and drug discovery. Key industries requiring this high-purity specialty chemical include pharmaceutical R&D, biotechnology, and academic research institutions.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis of novel nucleoside-based therapeutics, including potential antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate RNA modification pathways and thionucleoside metabolism.
• Molecular Biology: Employed in studies of tRNA structure and function, particularly for understanding the role of post-transcriptional modifications.
• Medicinal Chemistry: Serves as a building block for the design and synthesis of modified oligonucleotides with tailored properties.
• Diagnostic Reagent Development: Potential use in the development of assays and kits for detecting specific RNA modifications or related enzymes.
• Academic Research: A vital tool for universities and research institutes studying nucleic acid chemistry, epigenetics, and related life sciences.

Basic Information

Product Name	5-Methyl-2-Thiouridine
CAS No.	32738-09-3
Molecular Formula	C10H14N2O5S
Molecular Weight	274.29 g/mol
Synonyms	2-Thio-5-methyluridine; 5-Methyl-2-thiouridine; 5-Methyl-2-thio-uridine; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-4-one; m5s2U; 5-Methyl-2-thio-pseudouridine (related analog); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-Thiouridine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade chemicals, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.