Description

3,5-Bis(Trifluoromethyl)Benzyl Bromide is a versatile and highly functionalized organic intermediate characterized by its reactive benzyl bromide group and electron-withdrawing trifluoromethyl substituents. This compound is crucial for introducing the 3,5-bis(trifluoromethyl)benzyl moiety into complex molecular architectures, a modification that can dramatically alter physical properties like lipophilicity and metabolic stability. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, where the trifluoromethyl groups enhance blood-brain barrier penetration.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the introduced moiety contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in catalysis and as a component in metal-organic frameworks (MOFs) for specialized separation processes.
• Material Science: Employed in the production of specialty polymers and liquid crystals, where its structure imparts unique thermal and chemical resistance properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl systems.
• Fluorine Chemistry Research: An essential reagent for studying the effects of multiple fluorine atoms on molecular reactivity and biological activity in medicinal chemistry programs.

Basic Information

Item	Details
Product Name	3,5-Bis(Trifluoromethyl)Benzyl Bromide
CAS No.	32247-96-4
Molecular Formula	C10H5BrF6
Molecular Weight	319.05 g/mol
Synonyms	α-Bromo-3,5-bis(trifluoromethyl)toluene; (3,5-Bis(trifluoromethyl)phenyl)methyl bromide; 1-(Bromomethyl)-3,5-bis(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)benzyl bromide; 3,5-Di(trifluoromethyl)benzyl bromide; α-Bromo-α,α-bis(trifluoromethyl)toluene (related isomer); Benzyl bromide, 3,5-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Benzyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles to ensure the material meets your specific research or production requirements. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability, consistency, and reliability for critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.