Description

(R)-2-Fluoromandelic Acid CAS NO 32222-48-3 is a high-value, chiral fluorinated aromatic compound serving as a critical building block in advanced organic synthesis. Its primary importance lies in its role as a key intermediate for the production of enantiomerically pure pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. This product is essential for research and development laboratories, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in cardiovascular, central nervous system (CNS), and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the chiral fluorine moiety enhances target specificity and environmental persistence.
• Asymmetric Catalyst Ligand Precursor: Serves as a starting material for synthesizing chiral ligands used in asymmetric hydrogenation and other enantioselective catalytic processes.
• Fluorine Chemistry Research: A valuable reference standard and building block in academic and industrial research exploring the effects of fluorination on molecular properties (the "fluorine effect").
• Diagnostic Agent Development: Employed in the research phase for creating novel Positron Emission Tomography (PET) tracers and other imaging agents containing fluorine-18.
• Fine Chemical Production: Used in the multi-step synthesis of complex, high-value fluorinated fine chemicals and specialty materials.

Basic Information

Product Name	(R)-2-Fluoromandelic Acid
CAS No.	32222-48-3
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	(R)-2-Fluoromandelic Acid; (R)-(-)-2-Fluoromandelic Acid; (R)-α-Fluoromandelic Acid; (2R)-2-Fluoro-2-hydroxy-2-phenylethanoic Acid; (R)-2-Fluoro-2-phenylglycolic Acid; (R)-O-Fluoromandelic Acid; (R)-2-FMA; (R)-FMA
EINECS	Contact for details

Quality Control

Our (R)-2-Fluoromandelic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for chiral applications. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and titration for assay. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We adhere to cGMP guidelines where applicable to support our customers' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect purity and stability. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.