Description

(R)-Hydroxy-(4-Fluoro-Phenyl)-Acetic Acid Ethyl Ester is a high-value chiral building block and intermediate essential for the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. Its significance lies in the optically active (R)-configuration of the α-hydroxy acid moiety, which is critical for imparting specific biological activity in target molecules. This compound is primarily needed by pharmaceutical R&D and manufacturing sectors, especially for developing active pharmaceutical ingredients (APIs) with chiral centers.

Application

• Chiral Intermediate in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs) and other fluorinated APIs.
• Key Building Block for the production of angiotensin-converting enzyme (ACE) inhibitors and other cardiovascular agents.
• Precursor in the manufacture of enantiopure agrochemicals and specialty fine chemicals.
• Research Chemical for academic and industrial studies in asymmetric synthesis and medicinal chemistry.
• Starting Material for the preparation of fluorinated β-blockers and other receptor-targeting therapeutics.
• Standard Reference Compound for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	(R)-Hydroxy-(4-Fluoro-Phenyl)-Acetic Acid Ethyl Ester
CAS No.	32222-46-1
Molecular Formula	C10H11FO3
Molecular Weight	198.19 g/mol
Synonyms	(R)-Ethyl 2-Hydroxy-2-(4-fluorophenyl)acetate; (R)-(-)-2-Hydroxy-2-(4-fluorophenyl)acetic Acid Ethyl Ester; (R)-O-Desmethyl Venlafaxine Impurity; (R)-4-Fluoromandelic Acid Ethyl Ester; (R)-α-Hydroxy-4-fluorophenylacetic Acid Ethyl Ester; Ethyl (R)-(-)-2-Hydroxy-2-(4-fluorophenyl)acetate; (R)-FEMA
EINECS	Contact for details

Quality Control

Our (R)-Hydroxy-(4-Fluoro-Phenyl)-Acetic Acid Ethyl Ester is manufactured under strict quality systems to ensure high chiral purity and chemical consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles. We adhere to ICH guidelines for analytical method validation, ensuring data integrity and reliability for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.