Description

Calcitriol is the biologically active form of Vitamin D3, a potent secosteroid hormone essential for regulating calcium and phosphate homeostasis in the body. This high-purity compound is critical for advanced pharmaceutical research and manufacturing, where precise biological activity and stringent quality are non-negotiable. It is primarily utilized by the pharmaceutical, biotechnology, and advanced research sectors for developing treatments for conditions like hypocalcemia, osteoporosis, and renal osteodystrophy.

Application

• Pharmaceutical Active Ingredient: Key component in prescription medications for treating hypocalcemia in patients with chronic kidney disease and hypoparathyroidism.
• Osteoporosis Therapy: Used in formulations aimed at increasing bone mineral density and reducing fracture risk.
• Psoriasis Treatment: Incorporated into topical ointments and creams for managing plaque psoriasis.
• Biochemical Research: Serves as a critical reference standard and reagent in studies of Vitamin D metabolism, calcium signaling pathways, and bone biology.
• Dietary Supplement Development: Used in high-potency, prescription-strength nutritional supplements under medical supervision.
• Veterinary Medicine: Employed in treatments for calcium disorders in companion and livestock animals.

Basic Information

Product Name	Calcitriol
CAS No.	32222-06-3
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	1,25-Dihydroxycholecalciferol; 1,25-Dihydroxyvitamin D3; 1,25(OH)₂D₃; 1α,25-Dihydroxyvitamin D₃; 1α,25-Dihydroxycholecalciferol; Rocaltrol (trade name); Calcijex (trade name); (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,25-triol
EINECS	250-962-2

Quality Control

Our Calcitriol is manufactured under strict quality management systems to ensure it meets the highest standards for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes. Production can be aligned with cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or refrigerated (2-8°C) as specified. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.