Description

Propargyl-Peg14-Alcohol is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a terminal propargyl group and a hydroxyl terminus. This bifunctional linker is engineered for precision in bioconjugation and materials science, offering controlled reactivity for click chemistry applications. It is essential for researchers and manufacturers in pharmaceutical development, advanced material synthesis, and diagnostic reagent formulation who require reliable, well-defined PEG spacers.

Application

• Bioconjugation and Click Chemistry: Serves as a heterobifunctional crosslinker for coupling biomolecules (proteins, peptides, oligonucleotides) via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Pharmaceutical PEGylation: Used to modify therapeutic proteins and peptides to enhance solubility, stability, and circulation half-life.
• Polymer and Dendrimer Synthesis: Acts as a versatile building block or initiator for creating functionalized, biocompatible polymers and dendritic structures.
• Surface Functionalization: Enables the modification of nanoparticles, quantum dots, and biosensor surfaces with hydroxyl groups for further derivatization.
• Diagnostic Reagents: Utilized in the development of contrast agents, fluorescent probes, and assay components requiring precise linker chemistry.
• Hydrogel Formation: Participates in the synthesis of crosslinked hydrogel networks for drug delivery and tissue engineering applications.

Basic Information

Product Name	Propargyl-Peg14-Alcohol
CAS No.	32199-97-6
Molecular Formula	C31H60O15
Molecular Weight	648.79 g/mol
Synonyms	Propargyl-PEG14-OH; α-Propargyl-ω-hydroxy-tetradecaethylene glycol; 2,5,8,11,14,17,20,23,26,29,32,35,38,41-Tetradecaoxatetratetracont-43-yn-1-ol; Propargyl-PEG14; mPEG14-Propargyl; Propargyl-PEG 650 Alcohol; Alkyne-PEG14-OH; 14-Unit PEG Alkyne Alcohol
EINECS	Contact for details

Quality Control

Our Propargyl-Peg14-Alcohol is manufactured under strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing results from NMR (¹H and ¹³C), HPLC for purity and monodispersity, and FT-IR for functional group verification. We support cGMP-grade production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Complies with structure
Identification (IR)	Complies
Purity (HPLC)	≥ 95%
Average Molecular Weight	648.79 ± 5 Da
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.