Description

R-(+)-Cotinine is the dextrorotatory enantiomer of cotinine, a major metabolite of nicotine, distinguished by its high stereochemical purity. This compound is a critical reference standard and biochemical tool for research into nicotine metabolism, addiction mechanisms, and receptor interactions. It is essential for pharmaceutical R&D, analytical laboratories, and diagnostic kit manufacturers requiring a well-characterized, high-purity chiral standard.

Application

• Pharmaceutical Reference Standard: Primary metabolite standard for bioanalytical method development and validation in pharmacokinetic studies of nicotine and related therapeutics.
• Neuroscience & Addiction Research: Key reagent for investigating the pharmacological profile, receptor binding affinity, and metabolic pathways of nicotine in the central nervous system.
• Clinical Diagnostics: Calibrator and control material for the accurate quantification of cotinine levels in biological samples (e.g., urine, blood, saliva) for smoking cessation monitoring and exposure studies.
• Biochemical Assay Development: Used in the development of enzyme-linked immunosorbent assays (ELISAs) and other immunoassays for nicotine metabolite detection.
• Metabolite Synthesis: Serves as a chiral building block or intermediate in the organic synthesis of more complex nicotine-related metabolites or analogs for research purposes.
• Toxicology & Forensic Analysis: Provides a definitive standard for confirming nicotine exposure and use in forensic and workplace testing programs.

Basic Information

Product Name	R-(+)-Cotinine
CAS No.	32162-64-4
Molecular Formula	C10H12N2O
Molecular Weight	176.22 g/mol
Synonyms	(R)-(+)-Cotinine; (+)-Cotinine; (R)-Cotinine; (5R)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; Dextro-Cotinine; Cotinine enantiomer (R); S-(+)-Cotinine (obsolete); Nicotine metabolite R-form; 2-Pyrrolidinone, 1-methyl-5-(3-pyridinyl)-, (5R)-
EINECS	Contact for details

Quality Control

Our R-(+)-Cotinine is manufactured under controlled conditions to ensure high chiral purity and batch-to-batch consistency, suitable for demanding research and diagnostic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. We adhere to rigorous internal quality standards to meet the requirements for use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.