Description

2,2,2-Trifluoroethyl Formate is a versatile fluorinated ester building block with significant utility in advanced organic synthesis. Its primary value lies in its ability to introduce the trifluoroethoxy moiety, a key functional group that can dramatically alter the physical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability. The CAS number for this substance is 32042-38-9.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoroethyl group to modulate pharmacokinetics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved efficacy and environmental profile.
• Fluorinated Building Block: Serves as a reagent in organic chemistry for the preparation of more complex fluorinated esters, ethers, and other derivatives.
• Material Science: Potential use in the development of specialty polymers, coatings, and liquid crystals that benefit from the unique properties of fluorine.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel fluorinated compound libraries.

Basic Information

Product Name	2,2,2-Trifluoroethyl Formate
CAS No.	32042-38-9
Molecular Formula	C3H3F3O2
Molecular Weight	128.05 g/mol
Synonyms	Formic Acid 2,2,2-Trifluoroethyl Ester; Trifluoroethyl Formate; 2,2,2-Trifluoroethanol Formate; Ethanol, 2,2,2-trifluoro-, 1-formate; TFE Formate
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethyl Formate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high chemical purity and consistency. A Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatility loss.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.320 - 1.340
Density (20°C)	1.35 - 1.45 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.