Description

o-Desmethyl Mycophenolic Acid is a key pharmacologically active metabolite of mycophenolic acid, an important immunosuppressive agent. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical reference standards. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in immunology and transplant medicine research.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of mycophenolic acid and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance of mycophenolic acid-based therapeutics.
• Immunosuppressive Research: Used in preclinical and clinical research to understand the efficacy and safety profiles of immunosuppressive regimens, particularly in organ transplantation.
• Analytical Method Development: A critical component for developing and validating high-performance liquid chromatography (HPLC), LC-MS/MS, and other bioanalytical methods.
• Impurity Profiling: Employed as a known impurity standard to monitor and control the quality of mycophenolate mofetil and related active pharmaceutical ingredients (APIs).
• Clinical Trial Support: Used to measure metabolite levels in patient samples during clinical trials for therapeutic drug monitoring (TDM).

Basic Information

Product Name	o-Desmethyl Mycophenolic Acid
CAS No.	31858-65-8
Molecular Formula	C16H18O6
Molecular Weight	306.31 g/mol
Synonyms	7-Hydroxy-5-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-3-methylhept-5-enoic Acid; 7-O-Desmethyl Mycophenolic Acid; 7-Hydroxy Mycophenolic Acid; MPA 7-O-Glucuronide Aglycone; Mycophenolic Acid Metabolite; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic Acid (alternative numbering); Acyl Glucuronide of Mycophenolic Acid (hydrolyzed form).
EINECS	Contact for details

Quality Control

Our o-Desmethyl Mycophenolic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed chromatograms and spectral data to ensure traceability and compliance with research-grade standards. Specifications can be aligned with pharmacopeial guidelines (e.g., USP reference standard criteria) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.