Description

4-Maleimidobenzonitrile is a high-purity, bifunctional organic compound featuring both a maleimide and a benzonitrile group, making it a versatile and valuable building block for advanced synthesis. Its primary value lies in its ability to act as a heterobifunctional crosslinker, enabling the precise conjugation of biomolecules and polymers under mild conditions. This product is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors, particularly for developing antibody-drug conjugates (ADCs), functionalized surfaces, and specialty polymers.

Application

• Bioconjugation & ADC Development: A key reagent for site-specific conjugation of drugs, peptides, or fluorescent labels to antibodies and proteins via the maleimide-thiol "click" chemistry.
• Polymer Functionalization: Used to introduce reactive maleimide groups into polymer backbones or dendrimers for creating smart materials, hydrogels, and drug delivery systems.
• Surface Modification: Enables the covalent attachment of biomolecules to chips, nanoparticles, or other solid supports for biosensor and diagnostic assay development.
• Organic Synthesis Intermediate: Serves as a precursor for synthesizing more complex heterocyclic compounds and pharmaceutical intermediates, leveraging the reactivity of both functional groups.
• Peptide & Protein Labeling: Facilitates the stable labeling of cysteine-containing peptides and proteins for analytical and therapeutic purposes.
• Materials Science Research: Employed in the development of crosslinked networks and functional coatings with tailored properties.

Basic Information

Product Name	4-Maleimidobenzonitrile
CAS No.	31489-18-6
Molecular Formula	C11H6N2O2
Molecular Weight	198.18 g/mol
Synonyms	4-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)benzonitrile; 1-(4-Cyanophenyl)-1H-pyrrole-2,5-dione; p-Maleimidobenzonitrile; 4-Maleimidophenyl cyanide; N-(4-Cyanophenyl)maleimide; Maleimidobenzonitrile; 4-Cyanophenylmaleimide; 4-Maleimidobenzene carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Maleimidobenzonitrile is manufactured and tested under a strict quality management system to ensure consistency and reliability for critical applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and documentation excellence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants and storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.