Description

4-Fluoro-3-Hydroxyphenylacetic Acid is a fluorinated aromatic carboxylic acid derivative that serves as a versatile and high-value synthetic intermediate. Its molecular structure, featuring both a phenolic hydroxyl and an acetic acid group on a fluorinated benzene ring, makes it a critical building block for creating complex molecules with targeted biological activity. This compound is essential for research and development chemists and process engineers in the pharmaceutical and advanced materials sectors who require reliable, high-purity intermediates for their synthesis workflows.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Biochemical Research: Employed as a standard or reagent in biochemical assays and proteomics research due to its specific functional groups.
• Peptide Mimetics & Conjugates: Utilized to introduce fluorinated aromatic moieties into peptide chains, modifying their stability and binding properties.
• Polymer Modification: Acts as a monomer or cross-linking agent for creating specialty polymers with unique thermal and chemical resistance.

Basic Information

Product Name	4-Fluoro-3-Hydroxyphenylacetic Acid
CAS No.	31338-68-8
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	2-(4-Fluoro-3-hydroxyphenyl)acetic Acid; (4-Fluoro-3-hydroxyphenyl)acetic Acid; 3-Hydroxy-4-fluorophenylacetic Acid; 4-Fluoro-3-hydroxybenzeneacetic Acid; FA 13; 4-Fluoro-3-hydroxy-α-toluic Acid
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-Hydroxyphenylacetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents and bases. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.