Description

(3β)-Allopregnanolone 3-β-D-Glucuronide CAS NO 31300-87-5 is a high-purity conjugated metabolite of the endogenous neurosteroid allopregnanolone. This compound is of significant value as a critical reference standard and analytical tool in pharmaceutical research and clinical diagnostics. It is primarily required by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in neuroendocrinology, pharmacokinetic studies, and the development of biomarkers.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative analysis of allopregnanolone metabolites in biological matrices via LC-MS/MS or HPLC.
• Biomarker Research: Essential for developing and validating assays to study neurosteroid pathways related to neurological and psychiatric conditions.
• Preclinical & Clinical Studies: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies to understand the metabolism and excretion profiles of neuroactive steroids.
• Diagnostic Kit Development: Serves as a key calibrant in the manufacturing of diagnostic kits for hormonal and metabolic disorder testing.
• Academic Research: Utilized in university and institutional labs for fundamental research on GABA-A receptor modulation and neurosteroid function.
• Quality Control: Acts as an impurity marker or system suitability standard in the quality control of steroid-based pharmaceutical products.

Basic Information

Product Name	(3β)-Allopregnanolone 3-β-D-Glucuronide
CAS No.	31300-87-5
Molecular Formula	C27H42O9
Molecular Weight	510.62 g/mol
Synonyms	Allopregnanolone 3β-D-Glucuronide; 3α-Hydroxy-5α-pregnan-20-one 3β-D-Glucuronide; 5α-Pregnan-3α-ol-20-one 3β-Glucuronide; Pregnanolone Glucuronide; (3β,5α)-3-Hydroxypregnan-20-one 3-β-D-Glucopyranosiduronic Acid; THDOC Glucuronide (related); 3α,5α-THP Glucuronide; Allopregnanolone glucuronide conjugate
EINECS	Contact for details

Quality Control

Our (3β)-Allopregnanolone 3-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.