Description

1-(Chloromethyl)Pyrrolidin-2-One is a versatile and reactive heterocyclic building block featuring a pyrrolidinone core with a chloromethyl substituent. This compound is of significant value in organic synthesis, particularly in the pharmaceutical and agrochemical sectors, where it serves as a key intermediate for constructing more complex molecular architectures. Its reactive chloromethyl group makes it an ideal precursor for alkylation and further functionalization reactions. Industries involved in the research and production of active pharmaceutical ingredients (APIs), fine chemicals, and specialty materials are the primary users of this high-purity intermediate.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of various drug candidates, particularly those containing the pyrrolidinone pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its structure contributes to biological activity.
• Fine Chemical Production: Serves as a starting material or intermediate for creating complex specialty chemicals and functional materials.
• Linker in Bioconjugation: The reactive chloromethyl group can be utilized to attach molecules of interest in bioconjugation chemistry for drug delivery systems.
• Polymer Modification: Acts as a monomer or modifier in the synthesis of specialty polymers with tailored properties.
• Research & Development: An essential reagent in academic and industrial R&D labs for exploring new synthetic pathways and novel compounds.

Basic Information

Product Name	1-(Chloromethyl)Pyrrolidin-2-One
CAS No.	31282-95-8
Molecular Formula	C5H8ClNO
Molecular Weight	133.57 g/mol
Synonyms	1-(Chloromethyl)-2-pyrrolidinone; N-(Chloromethyl)-2-pyrrolidinone; 2-Pyrrolidinone, 1-(chloromethyl)-; 1-Chloromethyl-2-pyrrolidone; N-Chloromethylpyrrolidone; 1-(Chloromethyl)pyrrolidin-2-one; 1-Chloromethyl-2-pyrrolidinone; 31282-95-8
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)Pyrrolidin-2-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to meet the stringent requirements of our global clientele in advanced synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.