Description

5-(Acetamido)-N,N'-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-1,3-Benzenedicarboxamide is a high-purity, tri-iodinated organic compound specifically engineered as a key intermediate in the synthesis of advanced X-ray contrast media. This compound matters because it provides the essential iodine-rich aromatic core required for effective radiopacity, coupled with functional groups designed for enhanced solubility and biocompatibility. Pharmaceutical manufacturers and advanced chemical synthesis laboratories need this critical building block to develop next-generation non-ionic, low-osmolar contrast agents for diagnostic imaging procedures such as computed tomography (CT) and angiography.

Application

• Primary Intermediate for X-ray Contrast Media: Serves as the foundational chemical scaffold in the synthesis of non-ionic, monomeric contrast agents like Iopamidol and Ioversol.
• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: A critical raw material in multi-step organic synthesis processes under current Good Manufacturing Practice (cGMP) conditions.
• Research & Development: Used in academic and industrial R&D for developing novel iodinated compounds with improved safety and efficacy profiles.
• Diagnostic Imaging Agent Precursor: Essential for manufacturing agents used in urography, cerebral angiography, and spinal imaging.
• Specialty Chemical Synthesis: Employed in the creation of other complex, high-value iodinated aromatic compounds for various life science applications.

Basic Information

Item	Details
Product Name	5-(Acetamido)-N,N'-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-1,3-Benzenedicarboxamide
CAS No.	31127-80-7
Molecular Formula	C16H21I3N3O7
Molecular Weight	725.07 g/mol
Synonyms	5-Acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Iopamidol Intermediate; Ioversol Intermediate; 2,4,6-Triiodo-5-acetamido-N,N'-bis(2,3-dihydroxypropyl)isophthalamide; WIN 39424; SQ 22003; NSC 351358; 5-Acetamido-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamic acid
EINECS	Contact for details

Quality Control

Our 5-(Acetamido)-N,N'-Bis(2,3-Dihydroxypropyl)-2,4,6-Triiodo-1,3-Benzenedicarboxamide is produced and tested to meet the stringent requirements for pharmaceutical intermediates. We employ rigorous analytical protocols including HPLC, NMR, and ICP-MS to ensure high chemical purity, precise iodine content, and low levels of specified impurities. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing all test results against agreed specifications. Our quality system supports development under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Iodine Content	52.0 - 53.0 %
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Heavy Metals (ICP-MS)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.