Description

2,5-Difluoro-L-Phenylalanine is a non-natural, fluorinated derivative of the essential amino acid L-phenylalanine. This compound is of significant interest in pharmaceutical research and development, particularly as a key building block for the synthesis of novel peptide-based drugs and bioactive molecules. Its primary value lies in the strategic introduction of fluorine atoms, which can dramatically alter the metabolic stability, bioavailability, and binding affinity of parent compounds. This high-purity chiral intermediate is essential for researchers and manufacturers in advanced pharmaceutical synthesis, agrochemical development, and as a precursor for PET (Positron Emission Tomography) tracer ligands.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of fluorinated peptide drugs and protease inhibitors.
• PET Tracer Development: Serves as a precursor for fluorine-18 labeled compounds used in diagnostic imaging and oncology research.
• Agrochemical Research: Used in the development of novel, fluorinated pesticides and herbicides with enhanced activity and environmental profile.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate substrate specificity and enzyme mechanism due to its modified structure.
• Material Science: Potential monomer for creating specialized fluorinated polymers with unique surface properties.
• Academic & Contract Research: A valuable reagent for synthetic organic chemistry and medicinal chemistry programs in universities and CROs.

Basic Information

Product Name	2,5-Difluoro-L-Phenylalanine
CAS No.	31105-92-7
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	(S)-2-Amino-3-(2,5-difluorophenyl)propanoic acid; L-2,5-Difluorophenylalanine; 2,5-DFPA; 2,5-Difluoro-DL-phenylalanine (racemic mixture); 2,5-Difluorophenylalanine; F2Phe; 2,5-F2-Phe
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including chiral purity verification by HPLC, identity confirmation by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to ensure full traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.