Description

Benzonitrile, 4-Chloro-2-Hydroxy- is a versatile chlorinated hydroxybenzonitrile derivative, serving as a key synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both chloro and hydroxy substituents on the benzonitrile core, makes it a valuable building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides, where the chlorohydroxybenzonitrile moiety contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and advanced polymers due to its electron-withdrawing nitrile group and modifiable aromatic ring.
• Chemical Research & Development: A fundamental building block in academic and industrial R&D for exploring new heterocyclic compounds and functional materials.

Basic Information

Product Name	Benzonitrile, 4-Chloro-2-Hydroxy-
CAS No.	30818-28-1
Molecular Formula	C7H4ClNO
Molecular Weight	153.56 g/mol
Synonyms	4-Chloro-2-hydroxybenzonitrile; 2-Hydroxy-4-chlorobenzonitrile; 4-Chloro-2-cyanophenol; 2-Cyano-5-chlorophenol; 5-Chloro-2-hydroxybenzonitrile; 4-Chlorosalicylonitrile; 2-Hydroxy-4-chlorobenzene carbonitrile; NSC 403697
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Chloro-2-Hydroxy- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	145 - 149 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.