Description

L-Sotalol is a non-selective β-adrenergic receptor blocker (β-blocker) with additional Class III antiarrhythmic properties. This dual mechanism of action makes it a critical active pharmaceutical ingredient (API) for the formulation of medications used to manage serious cardiac arrhythmias. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on cardiovascular therapeutics. The compound L-Sotalol CAS NO 30236-31-8 is supplied as a high-purity material to meet stringent pharmacopeial standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiarrhythmic drug formulations for treating ventricular and supraventricular arrhythmias.
• Cardiovascular Research: A key reference standard and investigational compound in preclinical and clinical studies of cardiac electrophysiology.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of sotalol hydrochloride tablets.
• Analytical Standard: Used as a certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, and other analytical methods.
• Dosage Form Development: Employed in R&D for developing new drug delivery systems and optimizing tablet or capsule formulations.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research related to β-blocker therapy.

Basic Information

Product Name	L-Sotalol
CAS No.	30236-31-8
Molecular Formula	C12H20N2O3S
Molecular Weight	272.36 g/mol
Synonyms	L-Sotalol; (S)-Sotalol; (-)-Sotalol; Sotalol L-Isomer; Sotalol (S)-Enantiomer; 4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide (S-form); MJ 1999 (L-form); β-Cardone (enantiomer)
EINECS	Contact for details

Quality Control

Our L-Sotalol is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is tested against rigorous specifications for identity, purity, and potency. We provide comprehensive Certificates of Analysis (COA) that include data from tests such as chiral purity, assay, and related substances. The material is suitable for use under cGMP guidelines and can be supplied to meet relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.