Description

trans-Ethyl (1R,2R)-2-Cyanocyclopropane-1-Carboxylate is a high-value, enantiomerically pure chiral building block characterized by its strained cyclopropane ring functionalized with both cyano and ester groups. This compound matters for its critical role in asymmetric synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of enantiomerically pure pesticides and herbicides for enhanced efficacy and environmental safety.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and catalysts in stereoselective transformations.
• Fine Chemical Building Block: Employed in the research and development of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Material Science Research: Investigated for the synthesis of novel polymers and advanced materials with unique structural properties.

Basic Information

Product Name	trans-Ethyl (1R,2R)-2-Cyanocyclopropane-1-Carboxylate
CAS No.	3999-56-2
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	(1R,2R)-Ethyl 2-Cyanocyclopropanecarboxylate; (1R,2R)-trans-Ethyl 2-Cyanocyclopropane-1-carboxylate; Ethyl (1R,2R)-(-)-2-Cyanocyclopropanecarboxylate; (-)-trans-Ethyl 2-Cyanocyclopropanecarboxylate; (1R,2R)-trans-2-Cyano-1-cyclopropanecarboxylic Acid Ethyl Ester; trans-(1R,2R)-Cyclopropanecarboxylic Acid, 2-Cyano-, Ethyl Ester; Chiral Cyclopropane Ester Nitrile
EINECS	Contact for details

Quality Control

Our trans-Ethyl (1R,2R)-2-Cyanocyclopropane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with full specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.