Description

Boc-L-Tyrosine CAS NO 3978-80-1 is a protected derivative of the essential amino acid L-Tyrosine, featuring a tert-butoxycarbonyl (Boc) group on the amine functionality. This protection is critical for enabling selective peptide bond formation in complex organic syntheses, particularly in solid-phase peptide synthesis (SPPS). It is an indispensable building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis: A fundamental Nα-protected amino acid for the stepwise construction of peptides in both solution-phase and solid-phase methodologies.
• Pharmaceutical Intermediates: Serves as a key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) for hormone analogs, enzyme inhibitors, and other bioactive molecules.
• Bioconjugation & Probe Development: Used to incorporate the tyrosine phenol side chain into molecules for subsequent labeling, cross-linking, or affinity tagging in biochemical assays.
• Research & Development: Employed in academic and industrial R&D for studying protein structure-function relationships, enzyme mechanisms, and signal transduction pathways.
• Combinatorial Chemistry: A valuable scaffold in the generation of diverse chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Boc-L-Tyrosine
CAS No.	3978-80-1
Molecular Formula	C14H19NO5
Molecular Weight	281.30 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-tyrosine; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-hydroxyphenyl)propanoic acid; Boc-Tyr-OH; BOC-L-Tyrosine; Boc-Tyrosine; N-Boc-L-tyrosine; N-tert-Butoxycarbonyl-L-tyrosine; tert-Butyloxycarbonyl-L-tyrosine
EINECS	223-607-9

Quality Control

Our Boc-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Specific Rotation [α]D20	-4.0° to -6.0° (c=1 in Acetic Acid)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.