Description

8-Hydroxychlorpromazine is a significant metabolite and synthetic intermediate of the phenothiazine class of compounds. This compound matters for its critical role in pharmaceutical research, particularly in the study of drug metabolism and the development of analytical reference standards. It is primarily needed by research institutions, pharmaceutical development laboratories, and chemical manufacturers focused on producing high-purity intermediates for antipsychotic drug synthesis and metabolite identification.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of chlorpromazine and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Serves as a key analytical standard in pharmacokinetic and pharmacodynamic studies to understand the metabolic pathways of chlorpromazine.
• Organic Synthesis Intermediate: Acts as a crucial building block for the synthesis of more complex phenothiazine derivatives and related pharmaceutical compounds.
• Biochemical Research: Employed in studies investigating the biochemical mechanisms of action and side-effect profiles of antipsychotic medications.
• Quality Control (QC) Testing: Utilized by pharmaceutical QC laboratories to develop and validate analytical methods, such as HPLC and LC-MS, for impurity profiling.
• Academic Research: Used in university and institutional labs for fundamental research in medicinal chemistry and neuropharmacology.

Basic Information

Item	Detail
Product Name	8-Hydroxychlorpromazine
CAS No.	3926-67-8
Molecular Formula	C17H19ClN2OS
Molecular Weight	334.86 g/mol
Synonyms	8-Hydroxychlorpromazine; 2-Chloro-10-[3-(4-hydroxy-1-piperazinyl)propyl]phenothiazine; 8-OH-CPZ; Chlorpromazine 8-Hydroxy Metabolite; 8-Hydroxy-2-chloro-10-(3-dimethylaminopropyl)phenothiazine; 8-Hydroxy CPZ; 3926-67-8; 8-Hydroxy Chlorpromazine Hydrochloride (salt forms may vary)
EINECS	Contact for details

Quality Control

Our 8-Hydroxychlorpromazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere for long-term stability. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.