Description

Z-Gly-Glu-Oh is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of glycyl-glutamic acid. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), where it is used to introduce the Gly-Glu sequence while protecting the glutamic acid side chain. It is primarily required by pharmaceutical researchers and fine chemical manufacturers developing peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis Intermediate: A key protected fragment for the controlled assembly of longer peptide chains in both research and GMP manufacturing.
• Pharmaceutical Research: Used in the development of novel peptide drugs, hormones, and enzyme inhibitors targeting various diseases.
• Bioconjugation: Serves as a spacer or linker molecule in the synthesis of peptide-protein conjugates for antibody-drug conjugates (ADCs) or diagnostics.
• Biochemical Reagent: Employed in enzymatic studies and as a substrate analog for protease and peptidase research.
• Cosmetic Peptides: Potential raw material for the synthesis of bioactive peptides used in advanced skincare formulations.
• Academic Research: A standard reagent for teaching and investigating peptide coupling chemistry and protection/deprotection strategies.

Basic Information

Product Name	Z-Gly-Glu-Oh
CAS No.	3916-39-0
Molecular Formula	C15H18N2O7
Molecular Weight	338.31 g/mol
Synonyms	N-Carbobenzoxy-glycyl-L-glutamic acid; Z-Gly-Glu-OH; N-[(Benzyloxy)carbonyl]glycyl-L-glutamic acid; CBZ-Gly-Glu-OH; N-Cbz-glycyl-L-glutamic acid; Glycyl-L-glutamic acid N-carboxy anhydride, N-benzyloxycarbonyl derivative; L-Glutamic acid, N-[(benzyloxy)carbonyl]glycyl-
EINECS	223-485-4

Quality Control

Our Z-Gly-Glu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability. Keep container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in AcOH)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.