Description

4-Fluoro-2-Iodo-1-Methoxybenzene is a versatile fluorinated and iodinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of halogen atoms and a methoxy group, enabling selective functionalization for the construction of complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications in cross-coupling reactions and as a precursor for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those requiring fluorinated and iodinated aromatic cores for enhanced bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the fluorine and iodine substituents can modulate biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where halogenated aromatics are crucial.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, leveraging the reactive iodine atom for carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis or as a scaffold for creating metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for incorporating fluorine and iodine isotopes (e.g., 18F, 123I, 125I) into molecules for imaging and diagnostic applications.

Basic Information

Product Name	4-Fluoro-2-Iodo-1-Methoxybenzene
CAS No.	3824-22-4
Molecular Formula	C7H6FIO
Molecular Weight	252.03 g/mol
Synonyms	1-Fluoro-4-Iodo-2-Methoxybenzene; 2-Iodo-4-Fluoroanisole; 4-Fluoro-2-Iodoanisole; 2-Iodo-4-fluoro-1-methoxybenzene; 1-Methoxy-4-fluoro-2-iodobenzene; 4-Fluoro-2-iodoanisole; 2-Iodo-4-fluoromethoxybenzene; Anisole, 4-fluoro-2-iodo-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Iodo-1-Methoxybenzene undergoes rigorous quality testing to ensure compliance with industry standards. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, purity, and impurity profiles. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. Our quality management system supports the needs of research and cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.