Description

Boc-Phe-Osu is a highly reactive N-hydroxysuccinimide (NHS) ester derivative of Boc-protected phenylalanine, widely used as a key building block in peptide synthesis. This compound matters because it facilitates efficient and selective amide bond formation under mild conditions, crucial for constructing complex peptides and bioconjugates. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science industries for the development of therapeutic peptides, protein labeling, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the efficient incorporation of Boc-protected phenylalanine into growing peptide chains.
• Solution-Phase Peptide Coupling: Used for fragment condensation and the synthesis of medium to long-chain peptides in solution.
• Bioconjugation and Protein Labeling: Enables the site-specific attachment of peptides, dyes, or other molecules to proteins, antibodies, or surfaces.
• Preparation of Peptide Mimetics and Libraries: Essential for creating modified peptides and combinatorial libraries for drug discovery and screening.
• Intermediate for API Synthesis: Serves as a key intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) that contain phenylalanine motifs.
• Research & Development: A staple reagent in academic and industrial R&D labs for exploring new peptide-based therapeutics and diagnostics.

Basic Information

Product Name	Boc-Phe-Osu
CAS No.	3674-06-4
Molecular Formula	C18H22N2O6
Molecular Weight	362.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-phenylalanine N-succinimidyl ester; Boc-L-phenylalanine N-hydroxysuccinimide ester; Boc-L-Phe-OSu; Boc-Phenylalanine-OSu; N-Boc-L-phenylalanine succinimidyl ester; Nα-Boc-L-phenylalanine N-hydroxysuccinimide ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid 2,5-dioxopyrrolidin-1-yl ester; BOC-PHE-OSU
EINECS	Contact for details

Quality Control

Our Boc-Phe-Osu is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with each shipment to guarantee reproducible performance and supply chain reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (nitrogen or argon) after each use to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Melting Point	118°C - 122°C
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.