Description

1H-Benzimidazole-5-Carbonitrile, 2-(Trifluoromethyl)- CAS NO 3671-61-2 is a high-value, multi-functional heterocyclic building block characterized by its benzimidazole core, nitrile group, and trifluoromethyl substituent. This compound is critical for advanced research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by pharmaceutical, agrochemical, and specialty chemical manufacturers for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced fungicides, herbicides, and plant growth regulators.
• Material Science Precursor: Serves as a building block for functional polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments for high-performance applications.

Basic Information

Product Name	1H-Benzimidazole-5-Carbonitrile, 2-(Trifluoromethyl)-
CAS No.	3671-61-2
Molecular Formula	C9H4F3N3
Molecular Weight	211.15 g/mol
Synonyms	2-(Trifluoromethyl)-1H-benzimidazole-5-carbonitrile; 2-(Trifluoromethyl)-5-cyanobenzimidazole; 5-Cyano-2-(trifluoromethyl)benzimidazole; 1H-Benzimidazole-5-carbonitrile, 2-(trifluoromethyl)-; 3671-61-2; 2-Trifluoromethyl-1H-benzimidazole-5-carbonitrile; 2-Trifluoromethyl-5-cyanobenzimidazole
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production follows cGMP guidelines where applicable, and each batch is analyzed using advanced techniques like HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.