Description

H-Lys(4-Nitro-Z)-Oh is a protected derivative of the essential amino acid L-lysine, featuring a 4-nitrobenzyloxycarbonyl (4-Nitro-Z) protecting group on its side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains with high fidelity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of amino acids in automated peptide synthesis.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation & Probe Development: Serves as a modified lysine residue for creating labeled peptides or cross-linked biomolecules for diagnostic and research applications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Biochemical Tool Synthesis: Used to produce substrates, inhibitors, or affinity ligands for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	H-Lys(4-Nitro-Z)-Oh
CAS No.	3557-90-2
Molecular Formula	C15H21N3O6
Molecular Weight	339.35 g/mol
Synonyms	N6-(4-Nitrobenzyloxycarbonyl)-L-lysine; Nε-(4-Nitrobenzyloxycarbonyl)-L-lysine; Lys(4-NO2-Z)-OH; Fmoc-Lys(4-Nitro-Z)-OH (when referring to the Fmoc-protected variant); Nα-Boc-Nε-(4-nitrobenzyloxycarbonyl)-L-lysine (for Boc-protected variant); 4-Nitrobenzyl N-(5-amino-1-carboxypentyl)carbamate; (S)-2-Amino-6-((((4-nitrophenyl)methoxy)carbonyl)amino)hexanoic acid
EINECS	Contact for details

Quality Control

Our H-Lys(4-Nitro-Z)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material suitable for research and GMP-guided development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.