Description

2'-Deoxy-L-Thymidine is a vital nucleoside analog and the enantiomer of the naturally occurring D-form. This high-purity compound is essential for research and development in advanced pharmaceutical and life science applications, where precise stereochemistry is critical. It is primarily utilized by biotech and pharmaceutical companies engaged in oligonucleotide synthesis, antiviral research, and the development of novel diagnostic tools.

Application

• Oligonucleotide Synthesis: A key building block (phosphoramidite) for the solid-phase synthesis of L-nucleic acids (LNA) and Spiegelmers.
• Antiviral Research: Serves as a precursor or intermediate in the research and development of novel enantiomeric nucleoside analog prodrugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate stereospecificity and mechanism of action.
• Diagnostic Development: Employed in the creation of specialized probes and assays that require the unique properties of L-nucleosides.
• Pharmaceutical Intermediates: An important chiral intermediate in the multi-step synthesis of potential therapeutic agents.
• Academic & Institutional Research: Fundamental studies in chemistry, biochemistry, and molecular biology exploring the properties of enantiomeric nucleic acids.

Basic Information

Product Name	2'-Deoxy-L-Thymidine
CAS No.	3424-98-4
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	L-Thymidine; (-)-Thymidine; L-(-)-Thymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; (2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolane; L-dT
EINECS	222-312-3

Quality Control

Our 2'-Deoxy-L-Thymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.