Description

1-[[[(Triphenylmethyl)Amino]Acetyl]Oxy]-2,5-Pyrrolidinedione is a specialized chemical intermediate featuring a trityl-protected amino acid derivative conjugated to a succinimidyl ester. This compound matters for its role as a key building block in the synthesis of complex organic molecules, particularly in peptide and protein chemistry where selective protection and activation are required. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced drug discovery, process development, and the production of high-value active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: Acts as a protected amino acid active ester for the controlled coupling of specific amino acid residues in solid-phase and solution-phase peptide synthesis.
• Bioconjugation: Serves as a reactive intermediate for labeling proteins, antibodies, or other biomolecules with probes, tags, or drug molecules under mild conditions.
• Pharmaceutical Intermediates: A crucial precursor in the multi-step synthesis of novel therapeutic compounds, including targeted cancer therapies and enzyme inhibitors.
• Protecting Group Chemistry: Utilized in organic synthesis where the triphenylmethyl (trityl) group provides temporary protection for amine functionalities, allowing for selective reactions at other sites.
• Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating custom molecular libraries for screening.
• Process Chemistry: Used in the development and scale-up of efficient, high-yield manufacturing routes for complex organic molecules.

Basic Information

Product Name	1-[[[(Triphenylmethyl)Amino]Acetyl]Oxy]-2,5-Pyrrolidinedione
CAS No.	3397-28-2
Molecular Formula	C27H24N2O4
Molecular Weight	440.49 g/mol
Synonyms	N-(Triphenylmethyl)glycine N-hydroxysuccinimide ester; Trt-Gly-OSu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-(triphenylmethyl)glycine succinimidyl ester (common mis-association); Nα-Tritylglycine N-succinimidyl ester; NSC 339728; Glycine, N-(triphenylmethyl)-, 2,5-dioxo-1-pyrrolidinyl ester; 1-[[[(Triphenylmethyl)amino]acetyl]oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our 1-[[[(Triphenylmethyl)Amino]Acetyl]Oxy]-2,5-Pyrrolidinedione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity (IR, NMR), and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.