Description

Boc-Trp-Osu CAS NO 3392-11-8 is a high-purity, protected amino acid derivative widely used as a critical building block in peptide synthesis. Its core value lies in providing a robust and selective method for introducing the tryptophan residue while protecting the reactive amine group from unwanted side reactions during chain assembly. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries engaged in the development of novel peptides, peptidomimetics, and therapeutic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of amino acids, specifically for incorporating tryptophan into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical peptide coupling strategies for research-scale and industrial-scale production.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Employed to label proteins or other biomolecules with tryptophan analogs for research and diagnostic purposes.
• Combinatorial Chemistry: Utilized in libraries for drug discovery to create diverse arrays of compounds containing the tryptophan moiety.
• Biochemical Research: Fundamental tool for studying protein structure-function relationships and enzyme-substrate interactions.

Basic Information

Product Name	Boc-Trp-Osu
CAS No.	3392-11-8
Molecular Formula	C₂₁H₂₅N₃O₆
Molecular Weight	415.44 g/mol
Synonyms	N-α-Boc-L-tryptophan N-succinimidyl ester; N-(tert-Butoxycarbonyl)-L-tryptophan N-hydroxysuccinimide ester; Boc-L-Trp-OSu; Boc-Tryptophan-OSu; (S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid 2,5-dioxopyrrolidin-1-yl ester; tert-Butyloxycarbonyl-L-tryptophan N-hydroxysuccinimide ester; N-Boc-L-tryptophan succinimidyl ester
EINECS	Contact for details

Quality Control

Our Boc-Trp-Osu is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for each lot to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.