Description

Z-Met-Osu CAS NO 3392-01-6 is a high-purity, activated ester derivative primarily used as a key building block in peptide synthesis and bioconjugation chemistry. Its value lies in its reactivity as an amine-reactive crosslinker, enabling the efficient and selective formation of stable amide bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable reagents for developing novel therapeutics, antibody-drug conjugates (ADCs), and advanced biomaterials.

Application

• Peptide Synthesis: Serves as an activated ester for the efficient coupling of amino acids, particularly for introducing specific side-chain functionalities or labels.
• Bioconjugation & ADC Development: A critical reagent for linking cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides to create targeted therapies and diagnostic tools.
• Polymer & Material Science: Used to functionalize polymers, nanoparticles, and surfaces with amine-reactive groups for creating smart biomaterials, hydrogels, and drug delivery systems.
• Crosslinking Agent: Employed to create covalent crosslinks between biomolecules to study protein-protein interactions or to stabilize molecular structures.
• Proteomics Research: Utilized in chemical proteomics for labeling and enriching proteins to understand their function and interaction networks.
• Intermediate for Fine Chemicals: Acts as a versatile synthetic intermediate in the production of more complex pharmaceutical compounds and specialty chemicals.

Basic Information

Product Name	Z-Met-Osu
CAS No.	3392-01-6
Molecular Formula	C14H16N2O6S
Molecular Weight	340.35 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-L-methionine N-hydroxysuccinimide ester; Z-L-Methionine N-succinimidyl ester; Z-Met-OSu; Z-Methionine-OSu; Cbz-Met-OSu; N-Cbz-L-methionine N-hydroxysuccinimide ester; Nα-Carbobenzoxy-L-methionine N-succinimidyl ester; NSC 334381
EINECS	Contact for details

Quality Control

Our Z-Met-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.