Description

trans-Thiothixene CAS NO 3313-27-7 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the thioxanthene class of compounds. It is a critical building block in the synthesis of neuroleptic and antipsychotic medications, valued for its precise stereochemistry and chemical integrity. This product is essential for pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the manufacture of antipsychotic medications.
• Neuroleptic Drug Production: Key intermediate for drugs targeting schizophrenia and other psychotic disorders.
• Biomedical Research: Used as a reference standard and tool compound in pharmacological and neurological studies.
• Fine Chemical Manufacturing: Serves as a precursor for the synthesis of more complex thioxanthene derivatives.
• Analytical Standard: Employed in quality control laboratories for method development and validation (HPLC, GC).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	trans-Thiothixene
CAS No.	3313-27-7
Molecular Formula	C₂₃H₂₉N₃O₂S₂
Molecular Weight	443.62 g/mol
Synonyms	Thiothixene (trans-isomer); (Z)-Thiothixene; Tiotixene; Navane (trans); trans-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide; 3313-27-7; (Z)-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide
EINECS	Contact for details

Quality Control

Our trans-Thiothixene is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and GC. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support development projects requiring compliance with ICH guidelines and cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.