Description

Boc-L-Serine is a crucial N-α-protected derivative of the amino acid L-serine, widely used as a key building block in peptide synthesis. Its primary value lies in providing a temporary protective group for the amine functionality, allowing for selective and controlled chain elongation in solid-phase and solution-phase peptide chemistry. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis: A fundamental building block (Fmoc/Boc strategy) for the controlled assembly of peptide sequences in pharmaceutical research and development.
• Pharmaceutical Intermediates: Serves as a critical raw material in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Bioconjugation & Linker Chemistry: Utilized in the preparation of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other bioconjugates due to the reactivity of the serine side chain.
• Biochemical Research: Employed in studying enzyme mechanisms, protein structure-function relationships, and as a substrate or inhibitor in enzymatic assays.
• Combinatorial Chemistry: Used in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group is cleaved under mild acidic conditions, making it ideal for orthogonal protection schemes in complex organic synthesis.

Basic Information

Product Name	Boc-L-Serine
CAS No.	3262-72-4
Molecular Formula	C8H15NO5
Molecular Weight	205.21 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxypropanoic acid; N-α-tert-Butoxycarbonyl-L-serine; N-Boc-L-serine; Boc-Ser-OH; BOC-L-Ser; tert-Butyloxycarbonyl-L-serine; L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-; N-(tert-Butoxycarbonyl)-L-serine
EINECS	221-867-8

Quality Control

Our Boc-L-Serine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and chiral purity, NMR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]20/D	-4.5° to -6.0° (c=1 in AcOH)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.