Description

Trityl-L-Phenylalanine Diethylammonium Salt is a protected amino acid derivative that serves as a crucial building block in advanced organic synthesis. This compound is valued for its role in facilitating complex peptide coupling reactions while preventing unwanted side reactions at the reactive amine group. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key intermediate for the controlled, sequential addition of phenylalanine residues, particularly where side-chain protection is required.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptide sequences and small proteins in solution, offering flexibility in protecting group strategy.
• Pharmaceutical Research & Development: A critical reagent in the R&D of peptide-based therapeutics, hormones, and diagnostic agents.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening and drug discovery.
• Bioconjugation: Useful in the site-specific modification of peptides and proteins for creating antibody-drug conjugates (ADCs) or labeled biomolecules.
• Academic Research: A standard reagent in university and institutional labs for studying peptide structure, function, and synthesis methodologies.

Basic Information

Product Name	Trityl-L-Phenylalanine Diethylammonium Salt
CAS No.	3226-92-4
Molecular Formula	C32H36N2O2 • C4H11N
Molecular Weight	Approx. 537.73 g/mol (Free acid: 448.65 g/mol)
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine Diethylammonium Salt; Fmoc-Phe-OH • HN(Et)2; Fmoc-L-Phenylalanine Diethylamine Salt; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-phenylpropanoic acid - diethylamine (1:1); N-α-Fmoc-L-phenylalanine diethylammonium salt; Fmoc-Phenylalanine-DEA Salt; Fmoc-Phe-O-DEA; Fmoc-Phe-OH Diethylamine Salt
EINECS	Contact for details

Quality Control

Our Trityl-L-Phenylalanine Diethylammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and consistent performance in sensitive synthetic applications. We provide Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, including HPLC purity, chiral purity, and moisture content, to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider using an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.