Description

17Beta-Estradiol-16,16-D2 is a deuterium-labeled analog of the primary female sex hormone, estradiol. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and precision. It is a critical material for researchers and laboratories in pharmaceutical development, clinical diagnostics, and endocrinology studies. The product is supplied with high chemical purity and isotopic enrichment to meet the stringent demands of modern bioanalytical workflows.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of endogenous estradiol levels.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies for the development of hormone therapies and endocrine-disrupting compounds.
• Clinical Research & Diagnostics: Enables accurate quantification of estradiol in serum, plasma, and tissue samples for clinical studies and diagnostic assay development.
• Endocrinology & Toxicology: Supports research into hormonal regulation, reproductive biology, and the assessment of environmental endocrine disruptors.
• Stable Isotope Labeling Studies: Serves as a tracer in metabolic pathway analysis and isotope dilution techniques.
• Reference Material Production: Used by certified reference material (CRM) manufacturers to create calibrated standards for laboratory quality control programs.

Basic Information

Product Name	17Beta-Estradiol-16,16-D2
CAS No.	3188-46-3
Molecular Formula	C18H22D2O2
Molecular Weight	274.40 g/mol
Synonyms	Estradiol-16,16-d2; [16,16-D2]-17β-Estradiol; 1,3,5(10)-Estratrien-3,17β-diol-16,16-d2; Deuterated Estradiol; 17β-Estradiol-d2; D2-Estradiol; E2-d2
EINECS	221-679-4

Quality Control

Every batch of 17Beta-Estradiol-16,16-D2 is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for chemical purity and mass spectrometry for isotopic enrichment verification, to ensure compliance with research and diagnostic standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, isotopic purity, and identification data is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98 atom % D
Chemical Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.