Description

Glutaryl-Coenzyme A is a vital biochemical intermediate, specifically an acyl-CoA thioester derivative of glutaric acid. This compound plays a crucial role in cellular metabolism, particularly in the catabolic pathways of lysine, hydroxylysine, and tryptophan. It is an essential reagent for researchers and manufacturers in the life sciences, enabling the study and production of key metabolic components. Primary demand comes from the pharmaceutical, biotechnology, and academic research sectors for applications in enzymatic studies, metabolic pathway analysis, and high-purity biochemical synthesis.

Application

• Biochemical Research: Critical substrate for studying the enzymatic activity of glutaryl-CoA dehydrogenases and related enzymes in metabolic disorders.
• Pharmaceutical Development: Used as a reference standard and intermediate in the research of therapies targeting metabolic diseases like glutaric acidemia type I.
• Diagnostic Reagent Manufacturing: Employed in the formulation of enzyme assay kits for clinical diagnostics to detect specific metabolic pathway deficiencies.
• Enzymology Studies: Serves as a key reagent for kinetic studies, inhibitor screening, and characterizing enzyme mechanisms within mitochondrial fatty acid and amino acid oxidation pathways.
• Metabolomics & Systems Biology: Used as a quantitative standard in mass spectrometry-based metabolomic profiling to map and validate metabolic networks.
• High-Purity Biochemical Synthesis: Acts as a specialized building block for the synthesis of labeled compounds (e.g., isotopically labeled) for tracer studies.

Basic Information

Product Name	Glutaryl-Coenzyme A
CAS No.	3131-84-8
Molecular Formula	C₂₆H₄₂N₇O₁₉P₃S
Molecular Weight	897.70 g/mol
Synonyms	Glutaryl-CoA; Glutaryl-Coenzyme A, Lithium Salt; Coenzyme A, S-glutaryl-; Glutaryl-S-coenzyme A; S-Glutarylcoenzyme A; Glutaric Acid-CoA; 3-Carboxypropionyl-CoA; Glutaryl-CoA Lithium Salt
EINECS	221-525-8

Quality Control

Every batch of Glutaryl-Coenzyme A is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure they meet the exacting standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Tested for enzymatic reactivity

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.