Description

Bis(2,4-Dinitrophenyl)-L-Histidine is a specialized derivative of the amino acid L-histidine, modified with two 2,4-dinitrophenyl groups. This compound is significant as a key intermediate and a model substrate in advanced biochemical and pharmaceutical research, particularly for studying enzyme inhibition and protein modification. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutic agents and diagnostic tools.

Application

• Biochemical Research: Used as a model substrate or inhibitor in enzymatic studies, particularly for proteases and histidine-modifying enzymes.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of more complex molecules for drug discovery programs.
• Proteomics & Protein Labeling: Acts as a chemical probe for the selective modification and study of histidine residues in proteins.
• Analytical Chemistry Standard: Employed as a reference standard in chromatographic (HPLC) and spectroscopic analyses for method development and validation.
• Antibody-Drug Conjugate (ADC) Research: Investigated for its potential use in the development of novel linker-payload systems for targeted cancer therapies.

Basic Information

Product Name	Bis(2,4-Dinitrophenyl)-L-Histidine
CAS No.	3129-33-7
Molecular Formula	C18H14N8O10
Molecular Weight	502.35 g/mol
Synonyms	L-Histidine, Nα,Nτ-bis(2,4-dinitrophenyl)-; Nα,Nτ-Bis(2,4-dinitrophenyl)histidine; Di-DNP-histidine; Bis(DNP)-L-histidine; (2S)-2-Amino-3-[1-[2,4-bis(dinitrophenyl)amino]ethyl]-1H-imidazole-4,5-dione (tautomeric form); Histidine DNP derivative; 2,4-Dinitrophenyl histidine derivative
EINECS	Contact for details

Quality Control

Our Bis(2,4-Dinitrophenyl)-L-Histidine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.