Description

2-Fluoro-4-Methyl-5-Nitroanisole is a high-purity, multi-functional aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern, featuring fluorine, methyl, nitro, and methoxy groups, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development laboratories and production facilities in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex nitro- and fluoro-containing dyes and organic pigments.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry, including cross-coupling and nucleophilic substitution reactions.
• Liquid Crystal and Electronic Chemical: Potential building block for fluorinated components used in display technologies and organic electronics.

Basic Information

Product Name	2-Fluoro-4-Methyl-5-Nitroanisole
CAS No.	3108-02-9
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	1-Fluoro-2-methoxy-4-methyl-5-nitrobenzene; 2-Fluoro-4-methyl-5-nitro-1-methoxybenzene; 5-Nitro-2-fluoro-4-methylanisole; Benzene, 1-fluoro-2-methoxy-4-methyl-5-nitro-; 2-Methoxy-5-nitro-4-fluorotoluene
EINECS	221-460-4

Quality Control

Every batch of 2-Fluoro-4-Methyl-5-Nitroanisole is manufactured under a strict quality management system and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere if prolonged exposure is anticipated during use.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	70 - 74 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.