Description

4-Ethynylbenzonitrile is a versatile aromatic nitrile building block featuring a terminal alkyne functional group. This bifunctional structure is critical for advanced organic synthesis, enabling efficient cross-coupling and click chemistry reactions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for targeted therapies.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, liquid crystals, and advanced organic frameworks (MOFs/COFs).
• Click Chemistry Reagent: The terminal alkyne group enables efficient Huisgen 1,3-dipolar cycloaddition reactions with azides for bioconjugation and material labeling.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organometallic complexes.
• Organic Electronic Materials: A building block for π-conjugated systems used in organic light-emitting diodes (OLEDs) and semiconductors.

Basic Information

Product Name	4-Ethynylbenzonitrile
CAS No.	3032-92-6
Molecular Formula	C9H5N
Molecular Weight	127.14 g/mol
Synonyms	4-Cyanophenylacetylene; p-Ethynylbenzonitrile; 1-Ethynyl-4-cyanobenzene; 4-(Ethynyl)benzonitrile; Benzonitrile, 4-ethynyl-; 4-Ethynyl-benzonitrile; p-Cyanophenylacetylene; 4-Acetylenylbenzonitrile
EINECS	221-222-7

Quality Control

Our 4-Ethynylbenzonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP manufacturing standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.