Description

Cbz-Gly-Gly-Oet is a protected dipeptide derivative, widely utilized as a crucial building block in solid-phase peptide synthesis (SPPS). Its primary value lies in providing a controlled method for elongating peptide chains while protecting the N-terminus with the Cbz (carboxybenzyl) group, which is readily removed under mild hydrogenation conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Peptide Synthesis Intermediate: A fundamental building block for the controlled, stepwise synthesis of longer, complex peptide sequences in both research and GMP production.
• Pharmaceutical Research & Development: Used in the discovery and development of new peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation & Probe Development: Serves as a spacer or linker component in the creation of peptide-conjugated probes for diagnostic imaging, assay development, and drug delivery systems.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protease activity, and other fundamental biochemical processes where defined peptide sequences are required.
• Material Science: Can be incorporated into the design of peptide-based biomaterials, hydrogels, and surface coatings for medical and industrial applications.

Basic Information

Product Name	Cbz-Gly-Gly-Oet
CAS No.	3005-87-6
Molecular Formula	C₁₅H₂₀N₂O₅
Molecular Weight	308.33 g/mol
Synonyms	N-Carbobenzoxy-glycyl-glycine ethyl ester; Z-Gly-Gly-OEt; Benzyloxycarbonyl-glycyl-glycine ethyl ester; CBZ-Gly-Gly-OEt; Nα-Cbz-Gly-Gly-OEt; Glycine, N-[(phenylmethoxy)carbonyl]glycyl-, ethyl ester; Ethyl N-[(benzyloxy)carbonyl]glycylglycinate; NSC 334681
EINECS	221-111-5

Quality Control

Our Cbz-Gly-Gly-Oet is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with research and development specifications. Custom purity grades, including high-purity standards suitable for pharmaceutical R&D, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	82 - 86 °C
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.