Description

2-(Trifluoromethyl)Anisole is a versatile fluorinated aromatic building block, characterized by the presence of both a methoxy group and a trifluoromethyl group on the benzene ring. This unique structure makes it a valuable intermediate for introducing lipophilicity and metabolic stability into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of advanced active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display technologies and organic light-emitting diodes (OLEDs).
• Functional Polymer Monomer: Incorporated into specialty polymers to impart specific properties such as chemical resistance, thermal stability, and altered surface energy.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, fluorinated aromatic systems.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	2-(Trifluoromethyl)Anisole
CAS No.	395-48-2
Molecular Formula	C8H7F3O
Molecular Weight	176.14 g/mol
Synonyms	1-Methoxy-2-(trifluoromethyl)benzene; o-(Trifluoromethyl)anisole; 2-Methoxybenzotrifluoride; α,α,α-Trifluoro-o-cresol methyl ether; 2-Trifluoromethylphenyl methyl ether; o-Trifluoromethylanisole; 2-CF3-Anisole; 2-Methoxy-α,α,α-trifluorotoluene
EINECS	206-916-9

Quality Control

Our 2-(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and fluorides. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.25 - 1.30 g/cm³
Refractive Index (n20D)	1.440 - 1.450

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.