Description

4-(Trifluoromethyl)Mandelic Acid is a high-value fluorinated aromatic compound, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its importance stems from the unique properties imparted by the trifluoromethyl group, which enhances metabolic stability, lipophilicity, and bioavailability in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and anti-inflammatory therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the CF₃ group contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Advanced Material Research: Serves as a monomer or modifier in the synthesis of specialty polymers and liquid crystals with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring the introduction of a chiral, fluorinated mandelic acid moiety.

Basic Information

Product Name	4-(Trifluoromethyl)Mandelic Acid
CAS No.	395-35-7
Molecular Formula	C₉H₇F₃O₃
Molecular Weight	220.15 g/mol
Synonyms	α-Hydroxy-α-(trifluoromethyl)phenylacetic Acid; 2-Hydroxy-2-[4-(trifluoromethyl)phenyl]acetic Acid; (RS)-2-Hydroxy-2-(4-trifluoromethylphenyl)acetic Acid; (±)-4-(Trifluoromethyl)mandelic Acid; DL-4-(Trifluoromethyl)mandelic Acid; 4-(Trifluoromethyl)benzoglycolic Acid; p-Trifluoromethylmandelic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Mandelic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.