Description

2,2-Difluoroacetophenone CAS NO 395-01-7 is a versatile fluorinated aromatic ketone, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethyl ketone moiety, enabling precise molecular construction. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and pesticides where fluorine substitution enhances bioactivity and environmental stability.
• Ligand and Catalyst Development: Precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Used in the synthesis of fluorinated monomers for specialty polymers with tailored properties.
• Fluorine Chemistry Studies: A standard reagent for investigating nucleophilic addition and substitution reactions adjacent to a difluoromethylene group.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of complex, fluorinated target molecules under cGMP conditions where required.

Basic Information

Product Name	2,2-Difluoroacetophenone
CAS No.	395-01-7
Molecular Formula	C8H6F2O
Molecular Weight	156.13 g/mol
Synonyms	α,α-Difluoroacetophenone; 2,2-Difluoro-1-phenylethanone; Phenacylidene difluoride; Difluoromethyl phenyl ketone; 1-Phenyl-2,2-difluoroethanone; (Difluoroacetyl)benzene; DFAP
EINECS	206-904-5

Quality Control

Every batch of 2,2-Difluoroacetophenone is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.480 - 1.490
Density (g/mL, 20°C)	1.22 - 1.28

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.