Description

Alpha,β-Difluoro-β-Chlorostyrene is a versatile fluorinated and chlorinated styrene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and chlorine substituents, makes it a high-value intermediate for creating complex molecules with tailored properties. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to introduce specific halogenated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for introducing difluoromethyl and chlorovinyl groups.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where halogenated aromatic systems enhance bioactivity and environmental stability.
• Material Science Monomer: Serves as a specialty monomer for synthesizing fluorinated polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Liquid Crystal & OLED Materials: A valuable intermediate for creating halogenated aromatic cores used in electronic display and lighting technologies.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl and conjugated systems.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for exploring new fluorination methodologies and constructing complex molecular architectures.

Basic Information

Product Name	Alpha,β-Difluoro-β-Chlorostyrene
CAS No.	395-00-6
Molecular Formula	C8H5ClF2
Molecular Weight	174.57 g/mol
Synonyms	1-Chloro-2,2-difluoroethenylbenzene; (1-Chloro-2,2-difluorovinyl)benzene; 2-Chloro-1,1-difluoro-1-phenylethylene; β,β-Difluoro-β-chlorostyrene; α,β-Difluoro-β-chlorostyrene; Benzene, (1-chloro-2,2-difluoroethenyl)-; 395-00-6; (E/Z)-α,β-Difluoro-β-chlorostyrene (isomeric mixture)
EINECS	Contact for details

Quality Control

Our Alpha,β-Difluoro-β-Chlorostyrene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use. Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Isomeric Mixture)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.