Description

4-(Trifluoroacetyl)Toluene is a high-value aromatic trifluoromethyl ketone derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the introduction of the trifluoroacetyl group, which significantly alters the electronic and steric properties of target molecules, enhancing their metabolic stability and lipophilicity. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty materials industries, where precise fluorination is required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a fluorinated building block for electronic materials, contributing to the thermal stability and electro-optical performance of displays.
• Advanced Polymer Modifiers: Incorporated into specialty polymers to enhance chemical resistance, reduce surface energy, and improve weatherability.
• Organic Synthesis Reagent: Employed in Friedel-Crafts acylation and other reactions to introduce the -COCF3 moiety into complex organic frameworks for research and development.
• Dye & Pigment Intermediate: Used in the production of specialized fluorinated dyes and pigments with unique color fastness and solubility properties.

Basic Information

Item	Detail
Product Name	4-(Trifluoroacetyl)Toluene
CAS No.	394-59-2
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	4-Methyl-α,α,α-trifluoroacetophenone; p-(Trifluoroacetyl)toluene; 1-[4-Methylphenyl]-2,2,2-trifluoroethanone; 4-Methyltrifluoroacetophenone; α,α,α-Trifluoro-4-methylacetophenone; 4-Methyl-α,α,α-trifluoroacetophenone; p-Methyl-α,α,α-trifluoroacetophenone; 4'-Methyl-2,2,2-trifluoroacetophenone
EINECS	206-915-3

Quality Control

Our 4-(Trifluoroacetyl)Toluene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including GC, HPLC, and NMR to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to potential moisture sensitivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.