Description

Butanoic Acid, 2,4-Difluoro-3-Oxo-, Methyl Ester is a specialized fluorinated β-keto ester, a key building block in organic synthesis. This compound matters for its unique reactivity profile, offering a versatile handle for constructing complex fluorinated molecules, which are highly sought after in advanced material and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used as a key building block for developing novel herbicides, fungicides, and pesticides with enhanced efficacy and environmental profiles.
• Advanced Material Research: Serves as a monomer or modifier in the development of fluorinated polymers, coatings, and liquid crystals with unique thermal and chemical resistance properties.
• Organic Synthesis Reagent: Employed in Claisen condensation, Michael addition, and other carbon-carbon bond-forming reactions to introduce difluorinated ketone functionalities.
• Fluorine Chemistry Studies: An essential compound for academic and industrial research exploring the effects of fluorine substitution on molecular reactivity and bioactivity.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for custom synthesis projects requiring precise fluorination at specific molecular positions.

Basic Information

Product Name	Butanoic Acid, 2,4-Difluoro-3-Oxo-, Methyl Ester
CAS No.	392-64-3
Molecular Formula	C5H6F2O3
Molecular Weight	152.10 g/mol
Synonyms	Methyl 2,4-difluoro-3-oxobutanoate; 2,4-Difluoro-3-oxobutanoic acid methyl ester; Methyl 4,4-difluoroacetoacetate; 4,4-Difluoroacetoacetic acid methyl ester; 3-Oxo-2,4-difluorobutanoic acid methyl ester; DFAA methyl ester; Methyl 2,4-difluoroacetoacetate
EINECS	Contact for details

Quality Control

Our Butanoic Acid, 2,4-Difluoro-3-Oxo-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.