Description

S-Ethyl Trifluorothioacetate (CAS NO 383-64-2) is a versatile fluorinated building block essential for introducing the trifluoromethylthio (SCF₃) group into target molecules. This high-value intermediate is critical for enhancing the lipophilicity and metabolic stability of advanced chemical compounds. It is primarily sought by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key reagent for synthesizing drug candidates with improved bioavailability and membrane permeability via the SCF₃ moiety.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethylthio group contributes to enhanced biological activity.
• Material Science: Serves as a precursor for modifying polymer surfaces and creating specialty fluorinated materials.
• Organic Synthesis Building Block: Enables efficient trifluoromethylthiolation reactions under mild conditions for constructing complex molecules.
• Ligand and Catalyst Development: Employed in the research and development of novel ligands and catalysts for transition metal chemistry.

Basic Information

Product Name	S-Ethyl Trifluorothioacetate
CAS No.	383-64-2
Molecular Formula	C₄H₅F₃OS
Molecular Weight	158.14 g/mol
Synonyms	Trifluorothioacetic Acid S-Ethyl Ester; Ethyl Trifluoromethyl Thioacetate; Ethyl Trifluorothioacetate; S-Ethyl Trifluoromethanethioate; 2,2,2-Trifluoro-1-(ethylsulfanyl)ethanone; Acetic acid, trifluorothio-, S-ethyl ester; Trifluoromethyl Thioglycolic Acid Ethyl Ester
EINECS	206-849-1

Quality Control

Our S-Ethyl Trifluorothioacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed and upright to prevent leakage and concentration loss. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.