Description

4-(Trifluoromethyl)Phenacyl Bromide is a versatile and highly reactive organic bromide building block, characterized by the presence of a phenacyl bromide moiety and a trifluoromethyl group. This combination makes it a critical intermediate for introducing the trifluoromethylphenyl ketone functionality into more complex molecular architectures, a key step in the synthesis of advanced materials and bioactive compounds. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic ketone scaffold for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated monomers and polymers for advanced materials with unique optical, electronic, or surface properties.
• Chemical Biology Probes: Useful for synthesizing fluorinated probes and tags for studying biological processes and protein interactions.
• General Organic Synthesis: Acts as an alkylating agent and an electrophile in various nucleophilic substitution and condensation reactions to build complex organic molecules.

Basic Information

Product Name	4-(Trifluoromethyl)Phenacyl Bromide
CAS No.	383-53-9
Molecular Formula	C9H6BrF3O
Molecular Weight	267.04 g/mol
Synonyms	2-Bromo-1-[4-(trifluoromethyl)phenyl]ethanone; 4'-Trifluoromethylphenacyl Bromide; α-Bromo-4'-(trifluoromethyl)acetophenone; p-Trifluoromethylphenacyl Bromide; 1-(4-(Trifluoromethyl)phenyl)-2-bromoethan-1-one; 2-Bromo-4'-trifluoromethylacetophenone; 4-(Trifluoromethyl)phenacyl bromide; 4-Trifluoromethyl-ω-bromoacetophenone
EINECS	206-852-5

Quality Control

Every batch of 4-(Trifluoromethyl)Phenacyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.