Description

1,1,1-Trifluoro-2-Butanone is a versatile fluorinated ketone building block prized for its unique reactivity and physicochemical profile. Its value lies in introducing the trifluoromethyl group, a key motif for enhancing metabolic stability, lipophilicity, and bioavailability in advanced molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop next-generation products with improved performance characteristics.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethyl ketone moiety for biological activity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the CF3 group contributes to efficacy and environmental persistence.
• Organic Synthesis Building Block: Serves as a versatile reagent for nucleophilic addition reactions, Grignard reactions, and the preparation of more complex fluorinated compounds.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and other specialty materials with tailored surface properties and chemical resistance.
• Chemical Research & Development: A valuable tool in medicinal chemistry and process chemistry for exploring structure-activity relationships and optimizing synthetic routes.

Basic Information

Product Name	1,1,1-Trifluoro-2-Butanone
CAS No.	381-88-4
Molecular Formula	C4H5F3O
Molecular Weight	126.08 g/mol
Synonyms	1,1,1-Trifluorobutan-2-one; 2-Butanone, 1,1,1-trifluoro-; 3,3,3-Trifluoro-2-butanone; Trifluoroethyl methyl ketone; 1,1,1-Trifluoro-2-oxobutane; 3,3,3-Trifluorobutan-2-one; CF3COCH2CH3
EINECS	206-842-3

Quality Control

Our 1,1,1-Trifluoro-2-Butanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.20 g/mL
Boiling Point	~70-72°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.