Description

Methyl Pentafluoropropionate CAS NO 378-75-6 is a high-purity fluorinated ester, a key building block in advanced organic synthesis. This compound is valued for its ability to introduce the pentafluoropropionyl group, a moiety that significantly alters the physical and chemical properties of target molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced stability, bioavailability, or specific electronic characteristics.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs where the CF3CF2C(O)- group improves metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where fluorination enhances biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs) and dielectric materials, contributing to improved performance and thermal stability.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, granting them unique properties such as oil- and water-repellency, chemical resistance, and low surface energy.
• Analytical Chemistry Reagent: Utilized as a derivatization agent in Gas Chromatography (GC) and Mass Spectrometry (MS) for the analysis of amines, alcohols, and other compounds to enhance volatility and detection.
• Organic Synthesis Building Block: A versatile reagent for nucleophilic substitution and condensation reactions, enabling the construction of complex fluorinated architectures in R&D laboratories.

Basic Information

Product Name	Methyl Pentafluoropropionate
CAS No.	378-75-6
Molecular Formula	C4H3F5O2
Molecular Weight	178.06 g/mol
Synonyms	Methyl Perfluoropropionate; Methyl 2,2,3,3,3-Pentafluoropropionate; Pentafluoropropionic Acid Methyl Ester; Methyl PFP; MeO2CC2F5; Methyl Perfluoropropanoate; 2,2,3,3,3-Pentafluoropropanoic Acid Methyl Ester
EINECS	206-819-5

Quality Control

Our Methyl Pentafluoropropionate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency that meets the stringent requirements of fine chemical and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density at 20°C	1.40 - 1.45 g/mL
Refractive Index (n20D)	1.310 - 1.320

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.