Description

2,2,3,3-Tetrafluorocyclobutanemethanol is a versatile fluorinated building block characterized by a cyclobutane ring substituted with fluorine atoms and a hydroxymethyl group. This unique structure imparts valuable properties such as enhanced lipophilicity and metabolic stability, making it a critical intermediate for advanced material and pharmaceutical synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecules with tailored performance characteristics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorinated cyclobutane core can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty fluoropolymers with unique surface properties, chemical resistance, and low refractive indices.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for the construction of stereochemically defined, fluorinated compound libraries.
• Surface Active Agents: Potential use in the synthesis of fluorinated surfactants and coatings for applications requiring low surface energy and high repellency.

Basic Information

Product Name	2,2,3,3-Tetrafluorocyclobutanemethanol
CAS No.	378-17-6
Molecular Formula	C5H6F4O
Molecular Weight	158.10 g/mol
Synonyms	(2,2,3,3-Tetrafluorocyclobutyl)methanol; Tetrafluorocyclobutanemethanol; 2,2,3,3-Tetrafluorocyclobutane-1-methanol; Cyclobutanemethanol, 2,2,3,3-tetrafluoro-; 1-(Hydroxymethyl)-2,2,3,3-tetrafluorocyclobutane; 378-17-6; Perfluorocyclobutanemethanol (incorrect but common search term)
EINECS	Contact for details

Quality Control

Our 2,2,3,3-Tetrafluorocyclobutanemethanol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.