Description

1,4-Difluorobutane (CAS NO 372-90-7) is a valuable fluorinated alkane building block, prized for its role in introducing fluorine atoms into complex molecular architectures. Its high volatility makes it an effective solvent and reagent in specialized synthetic pathways where controlled evaporation is critical. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to enhance product properties through fluorination.

Application

• Pharmaceutical Intermediate: Serves as a key fluorinated synthon in the development of active pharmaceutical ingredients (APIs) to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the fluorine moiety can increase efficacy and environmental persistence.
• Specialty Solvent: Acts as a highly volatile solvent for precision cleaning, extraction, and as a reaction medium in sensitive chemical processes.
• Polymer & Material Science: Employed as a monomer or modifier in the synthesis of fluoropolymers, imparting desirable properties like chemical resistance and low surface energy.
• Refrigerant & Propellant R&D: Investigated as a potential component in next-generation, low-global-warming-potential (GWP) refrigerant blends and aerosol propellants.
• Organic Synthesis Reagent: Functions as an alkylating agent or as a source of fluorine in various nucleophilic substitution and coupling reactions.

Basic Information

Product Name	1,4-Difluorobutane
CAS No.	372-90-7
Molecular Formula	C4H8F2
Molecular Weight	94.10 g/mol
Synonyms	Butane, 1,4-difluoro-; 1,4-DFB; Difluorobutane; Tetrafluoroethane (common misnomer, clarify); Fluorocarbon 254fb (potential trade designation); 1,4-Bis(fluoranyl)butane (IUPAC-style); F(CH2)4F
EINECS	206-758-0

Quality Control

Our 1,4-Difluorobutane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated industries. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and maintain purity. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Non-volatile Residue	≤ 0.01%
Acidity (as HF)	≤ 0.005%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.